If coadministration of CYP3A4 inhibitors with fentanyl is critical, keep track of patients for respiratory depression and sedation at Repeated intervals and consider fentanyl dose adjustments until finally stable drug effects are accomplished.
lumacaftor/ivacaftor will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
If you should go to A&E, usually do not travel yourself. Get somebody else to travel you or demand an ambulance.
olanzapine/samidorphan decreases effects of fentanyl by pharmacodynamic antagonism. Contraindicated. Samidorphan elicits opioid antagonistic effects and boosts risk of precipitating acute opioid withdrawal in patients dependent on opioids.
If coadministration of CYP3A4 inhibitors with fentanyl is important, monitor patients for respiratory depression and sedation at frequent intervals and consider fentanyl dose adjustments right up until stable drug effects are obtained.
diazepam buccal and fentanyl both equally boost sedation. Prevent or Use Alternate Drug. Restrict use to patients for whom alternate treatment options are inadequate
It's not ordinarily a problem. Having said that, you could potentially get withdrawal symptoms when you end using it quickly.
asenapine transdermal and fentanyl each raise sedation. Steer clear of or Use Alternate Drug. Limit use to patients for whom different treatment options are inadequate
Concomitant utilization of opioids with benzodiazepines or other central nervous system (CNS) depressants, which includes alcohol, may possibly cause profound sedation, respiratory depression, coma, and death; reserve concomitant prescribing to be used in patients for whom different treatment options are insufficient; limit dosages and durations to least demanded; fentanyl deaths per year united states follow patients for signs and symptoms of respiratory depression and sedation
If you should go to A&E, never drive yourself. Get someone else to drive you or call for an ambulance.
fentanyl will improve the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Increased flibanserin adverse effects may perhaps occur if coadministered with numerous weak CYP3A4 inhibitors.
lemborexant, fentanyl. Possibly increases effects in the other by sedation. Modify Therapy/Watch Intently. Dosage adjustment might be required if lemborexant is coadministered with other CNS depressants because of potentially additive effects.
fosphenytoin will lessen the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of fentanyl with CYP3A4 inducers could lead on to some lessen in fentanyl plasma concentrations, not enough efficacy or, probably, advancement of the withdrawal syndrome in a very individual who's got made physical dependence to fentanyl.
ferric maltol, fentanyl. Both boosts levels in the other by unspecified interaction mechanism. Modify Therapy/Keep an eye on Closely. Coadministration of ferric maltol with selected oral medications could decrease the bioavailability of both ferric maltol and several oral drugs.